Add all of the spices together in a small mixing bowl and whisk until evenly combined. Spread them all over the roast until it's evenly coated.
3-4 lb eye of round roast, 2 tsp garlic powder, 2 tsp dried oregano, 2 tsp smoked paprika, 2 tsp coarse salt
Add the oil to a large skillet set over medium high heat. When hot add the roast and sear on all sides until evenly browned. Transfer to a waiting plate and set aside.
2 tbsp extra virgin olive oil
Lower the heat to medium and add the onion and garlic to the skillet. Saute them for 3-4 minutes, until tender. Stir in the paste and continue cooking for 1 minutes.
1 large yellow onion, 4 cloves garlic, 1 tbsp tomato paste
Add the wine to the skillet and stir well to deglaze the pan, making sure to scrape up any stuck on browned bits.
1 - 1 1/4 cups red wine
Bring the mixture to a simmer, then remove from heat and stir in the thyme and brown sugar until evenly combined. Pour this mixture into the bowl of your slow cooker.
5-6 sprigs fresh thyme, 1 tbsp brown sugar
Add the meat to the slow cooker and add the vegetables around the meat. Pour in the broth, around and not over the meat.
1 - 1 1/2 cups beef broth, 1 lb baby potatoes, 3 large carrots
Cover and cook on LOW for for 8 hours, or on HIGH for 5-6 hours, until the meat is fork tender.
Carefully transfer the hot roast to a serving platter, then arrange the vegetables around it. Loosely tent with foil and set aside while you prepare the gravy.